Could Nutrient Deficiencies Affect Your Hormones, Mood, and Energy?
Feeling tired, struggling with mood changes, or experiencing new acne during perimenopause?Â
Hormones may be part of the picture, but nutrients such as folate, iron, and vitamin B12 also support important functions throughout the body.
At Hormone Balance Center in Fishers, Indiana, Dr. Roger Spahr takes a functional and integrative approach to health that considers the bigger picture, including hormone-related concerns and other factors that may affect overall wellbeing.

The Connection Between Nutrients and Hormone Health
Your body relies on vitamins, minerals, and enzymes to carry out essential processes. These include producing red blood cells, supporting nerve function, and creating and regulating chemical messengers in the brain.
When nutrient levels are inadequate, some people may experience symptoms such as fatigue, weakness, or neurological changes. However, these symptoms can have many causes, which is why identifying the underlying issue matters.
Three nutrients worth understanding are folate, iron, and vitamin B12.
1. Folate and Mood: What Is the Connection?
Folate, also known as vitamin B9, helps the body carry out essential cellular processes, including DNA synthesis and methylation reactions. These processes also contribute to pathways involved in neurotransmitter function.
Research has found an association between low folate status and depression in some populations. However, this does not mean low folate is the cause of every mood concern, or that taking folic acid will resolve depression.
If you experience persistent mood changes, anxiety, or low energy, a healthcare provider can help evaluate possible contributors, including nutritional status, sleep, medications, and hormonal changes.
2. Iron and Energy
Iron helps your body produce hemoglobin, which carries oxygen in your blood. It also plays a role in several enzymes involved in normal brain function.
Low iron levels can contribute to fatigue and weakness, particularly when iron deficiency leads to anemia. But taking iron when you do not need it can be harmful, so supplementation should be guided by an appropriate evaluation.
If persistent tiredness is affecting your daily life, ask your healthcare provider whether checking your iron status may be appropriate.
3. Vitamin B12, Memory, and Long-Term Medication Use
Vitamin B12 supports healthy nerve function and red blood cell formation. A deficiency can cause fatigue and neurological symptoms, and in some cases may affect memory or other cognitive functions.
Certain medications can also influence nutrient absorption. Proton pump inhibitors (PPIs), such as omeprazole, reduce stomach acid and may interfere with the absorption of vitamin B12 from food. This does not mean everyone taking these medications will develop a deficiency, but long-term use may be a relevant part of your medical history.
If you take acid-reducing medication regularly and have concerns about fatigue, memory, or possible nutrient deficiencies, discuss them with your healthcare provider. Do not stop a prescribed medication on your own.
4. Why Hormone Changes Can Coincide With New Acne
Some women begin experiencing acne around the chin, mouth, or jawline during perimenopause or menopause, even if they rarely had breakouts earlier in life.
Hormonal changes during the menopause transition can contribute to these skin changes. However, acne has several possible causes, and its appearance alone cannot confirm a hormone imbalance or a vitamin deficiency.
A personalized evaluation can help determine which factors may be contributing and what treatment options make sense for your situation.
5. Hormone Metabolism and the Bigger Picture
Hormone activity involves more than the amount of a hormone measured in a blood test. The body also uses enzymes and interconnected biochemical pathways to process hormones and neurotransmitters.
For example, the enzyme catechol-O-methyltransferase (COMT) participates in the breakdown of certain neurotransmitters, including dopamine and norepinephrine, as well as catechol estrogens.
These pathways are complex, and symptoms alone cannot establish that a particular enzyme or gene is responsible for how someone feels. This is one reason why a thorough clinical assessment is more useful than assuming that one hormone or nutrient explains everything.
How a More Comprehensive Approach for Nutrient Deficiency Can Help
At Hormone Balance Center, Dr. Roger Spahr's functional and integrative approach considers hormone-related symptoms within the context of a person's overall health.
Depending on your symptoms and medical history, your provider may discuss:
Your current symptoms, health history, and medications.
Whether hormone testing or other laboratory tests are appropriate.
Possible nutrient deficiencies and other contributors to fatigue or mood changes.
How to evaluate hormone-related concerns alongside other aspects of your health.
Whether any treatment or supplementation is appropriate for your individual needs.
Not everyone needs the same tests or treatments. The goal is to identify relevant factors and make informed decisions based on your individual circumstances.
The Bottom Line
Hormone changes can affect how you feel, but they may not explain every symptom. Folate, iron, vitamin B12, medications, and other health factors may also deserve consideration when you're experiencing persistent fatigue, mood changes, or unexpected skin concerns.
If you're looking for a more comprehensive approach to hormone health, Hormone Balance Center can help you explore your concerns with Dr. Roger Spahr in Fishers, Indiana.
Ready to discuss your hormone health?
Contact Hormone Balance Center to learn more about your options.
Hormone Balance Center
9748 Lantern Rd., Fishers, IN 46037
Phone: 317-606-8640
Medical disclaimer: This article is for educational purposes only and does not diagnose or treat any condition. Symptoms discussed here may have multiple causes. Testing and treatment should be individualized with a qualified healthcare professional.






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